Podus 100

Podus 100

Cefpodoxim 100mg

Alias productpodus-100-345
Number of items

Each package (1.5 g) of finished product contains:

Cefpodoxim proxetil is equivalent to Cefpodoxime ......... 100mg

Excipients eg ...................................................... .1 package.

(Excipients: White sugar, microcrystaline cellulose, aspartame, colloidal sillicon dioxide magnesium stearate, strawberry flavor).

Dosage form: powdered oral suspension.

Cefpodoxime is the third-generation cephalosporin antibiotic. In countries with low antibiotic rates, Cefpodoxime is highly resistant to the attack of beta-lactamases produced by Gram (-) and Gram (+) cocci.

In principle, Cefpodoxime is active against Gram stain (Streptococcus pneumoniae), Streptococcus groups A, B, C and Staphylococcus aureus, S.epidermidis. Whether or not to produce beta-lactamase. However, the drug has no effect against isoxazolyl-penicillin-resistant staphylococci due to altered penicillin-binding proteins (resistant to S. aureus and methicillin-resistant MRSA).

Cefpodoxime is also effective against Gram (-), Gram (+) and Gram (-) germplasm. The drug is active against Gram (-) bacteria causing serious diseases such as E.coil, Klebsiella, Proteus mirabills and Cetrobacter.

In contrast to other oral cephalosporins, Cefpodoxime is stable with beta-lactamase produced by Haemophilus influenzae, Moraxella catarrhalis and Neisseria.

Cefpodoxime has little effect on Proteus vulgaris, Enterobacter, Serratia marcesens and Clostridium perfringens. These bacteria are sometimes completely resistant.

+ Absorption: Cefpodoxime proxetil has little antibacterial effect when it is not hydrolyzed to cefpodoxime in the body. Cefpodoxime proxetil is absorbed through the gastrointestinal tract.

+ Distribution:   The bioavailability of Cefpodoxime is about 50%. This bioavailability increases with the use of cefodoxime with food. The serum half-life of Cefpodoxime is 2.1 to 2.8 hours for patients with normal renal function. Serum half-life increases to 3.5-9.8 hours in people with impaired renal function. After a dose of Cefpodoxime, in healthy adults with normal renal function, plasma concentrations are reached within 2-3 hours and a mean of 1.4ug / ml; 2.3ug / ml for doses of 100mg, 200mg, 400mg.

About 40% of cefpodoxime binds to plasma proteins.

+ Metabolism: is metabolized by non-specific esterases, possibly in the intestinal wall,   into cefpodoxime metabolites.

+ Discharge: The drug is excreted unchanged through glomerular filtration and excretion of the renal tubules. About 29 to 38% of the dose is eliminated within 12 hours in adults with normal renal function. No biological changes in kidney and liver. Drugs are excreted to a certain degree when hemodialysis.

+ Treatment of mild to moderate diseases in the lower respiratory tract, including community-acquired pneumonia due to susceptible strains of Streptococcus pneumonia or Haemophilus influenza (including beta-lactamase-producing strains) and batch Acute emesis of chronic bronchitis caused by susceptible strains of S. pneumoniae and by H. influenza or Moraxella catarrhalis, does not produce beta-lactamase.

+ Treatment of acute otitis media caused by S. pneumoniae, H. influenza (including beta-lactamase-producing strains) or B. catarrhalis.

+ Cefpodoxime is also used to treat uncomplicated mild to moderate irritant nephritis (bacterial conjunctivitis) caused by E. coli, Klebsiella pneumonia, Proteus mirabilis or Staphylococcus saprophyticus.

+ Cefpodoxime is used to treat acute, uncomplicated gonorrhea, cervical or rectal endometrium of women and gonorrhea in the urethra of women and men, caused by strains with or without created Penicillinase of Neisseria gonorrhea.

+ Cefpodoxime is also used to treat mild to moderate bacterial skin infections and skin organisms caused by Staphylococcus aureus to produce penicillinase and susceptible strains of Streptococcus pyogenes.

Put the total dose of each pack in 5 ml of water, stirring before drinking.

- Adults and children over 13 years old:

  • Treatment of acute exacerbation of chronic bronchitis or acute pneumonia to community-acquired pneumonia: The usual dose is: Take 2 capsules twice daily, take 10 or 14 days corresponding.
  • For sore throats and / or mild to moderate inflammation of the amygdala or mild or moderate uncomplicated urinary tract infections: The usual dose is: Take 1 capsule twice daily, 5-10 days Or 7 days respectively.
  • For skin infections and mild to moderate skin disorders; The usual dose is: Take 4 times a day, 2 times a day, 7-14 days.
  • Treatment of uncomplicated gonorrhea urethritis in men, women and rectal and rectal diseases and cervical endometrium in women. Take a single dose of 200mg, followed by oral doxycylics to prevent Chlamydia infection.

- Children:

  • Treatment of acute otitis media in children 12 years of age: Usual dose: 5mg / kg body weight / time (maximum 200mg) x 2 times daily; Or take 10mg / kg body weight / time (maximum 400mg) x 1 / day, use in 10 days
  • To treat other infectious diseases for children over 9 years of age: 100mg twice daily.

Dosage for patients with renal impairment: Must decrease depending on the degree of kidney failure. For patients with a creatinine clearance less than 30 ml / min and without hemodialysis, the dose is usually given at intervals of 24 hours. Beauties are hemodialysis, the usual dose is 3 times a week.

Not recommended for patients allergic to cephalosporins and people with porphyria. Children under 15 days of age.


  • Before initiating treatment with cefpodoxime, a thorough investigation of the patient's history of allergy to cephalosporin, penicillin or other drugs should be made.
  • It should be used with caution in penile hypersensitivity, renal insufficiency and in pregnancy or lactation.
  • Follow up and symptoms of anaphylaxis shock in the first dose.
  • If there is a hypersensitivity reaction occurring during treatment with cefpodoxime, it should be discontinued and appropriate therapy (eg, epinephrine, corticosteroid, and oxygen maintained) should be used.
  • Long-term use can lead to bacterial and fungal infections, especially Clostridium difficile infection that causes diarrhea and diarrhea. The safety and efficacy of the drug has not been determined for infants under 2 months of age.

Use for pregnant and lactating women:

  • Pregnancy: There are no references to the use of cefpodoxime during pregnancy. However, cephalosporins are generally considered safe for use in pregnancy.
  • Breastfeeding: Cefpodoxime is secreted in low concentrations breast milk. Although low concentrations, three problems still exist for children who are breastfed with cefpodoxime: gastrointestinal dysfunction, direct effects on the infant and bacterial culture results, If you have to do antibiotics when fever.

Use drugs when driving machinery operators: drugs cause headaches, dizziness, face shield should not be used for driving or operating machinery.

  • Absorption of cefpodoxime decreases with anti-acid, thus avoiding cefpodoxime with anti-acid and antihistamine H2.
  • Probenecid reduces renal excretion of cefpodoxime.
  • Cefpodoxime's activity may be concomitant with concomitant use of uric acid.

Cefpodoxime can reduce the activity of a live typhoid vaccine.

  • Test from glucose: A counterfeit positive for glucose in urine can occur with Benedict or Fehling solution or copper sulfate.
  • With diuretics: do renal toxicity.

Unwanted effects of the drug

  • Common: headache, dizziness, dizziness; Digestive (nausea, vomiting, diarrhea, abdominal pain); Allergic reactions (rash, urticaria, itching.
  • Less common: allergic reactions (reactions such as seroconversion to hives, fever and joint pain and anaphylactic reaction); Skin (erythema multiforme); Gan (transient hepatitic liver enzyme disorder and cholestatic jaundice).
  • Rare: Blood (eosinophilia, blood disorders); Kidney (renal interstitial nephritis); Central nervous system (increased activity, agitation, difficulty falling asleep, confusion, hypertonia, dizziness).

Overdose and treatment

In case of overdose symptomatic treatment. Cases of overdose may occur especially in patients with renal failure and encephalitis. Overdose cases in patients with encephalitis can be reversible when cefpodoxime levels decrease.

Signs commonly used and recommended: no reports.

Storage conditions and shelf life

Storage: In dry places, the heat is below 30oC.

Shelf life: 24 months from date of manufacture. Do not use expired drugs.

  • Note: When you see the package is moldy, color change, drug labels printed batches, HD blurred ... or other suspicious expression must bring the drug to ask the seller or place of production according to the address in the application. .


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