In principle, Cefpodoxime is active against Gram stain (Streptococcus pneumoniae), Streptococcus groups A, B, C and Staphylococcus aureus, S.epidermidis. Whether or not to produce beta-lactamase. However, the drug has no effect against isoxazolyl-penicillin-resistant staphylococci due to altered penicillin-binding proteins (resistant to S. aureus and methicillin-resistant MRSA).
Cefpodoxime is also effective against Gram (-), Gram (+) and Gram (-) germplasm. The drug is active against Gram (-) bacteria causing serious diseases such as E.coil, Klebsiella, Proteus mirabills and Cetrobacter.
In contrast to other oral cephalosporins, Cefpodoxime is stable with beta-lactamase produced by Haemophilus influenzae, Moraxella catarrhalis and Neisseria.
Cefpodoxime has little effect on Proteus vulgaris, Enterobacter, Serratia marcesens and Clostridium perfringens. These bacteria are sometimes completely resistant.